The ease and minimally invasive access through venipuncture and the potential to manifest any disease process anywhere in the body as a change in plasma protein composition makes plasma proteomics an attractive field of study. CD Genomics provides professional plasma proteomics analysis services to promote the research and development of blood proteomics.
Plasma is the liquid part of blood. Approximately 55% of our blood is plasma and the remaining 45% is red blood cells, white blood cells, and platelets suspended in the plasma. Plasma contains 7% of important proteins, such as albumin, gamma globulin, and anti-platelet factors, and 1% of mineral salts, sugars, fats, hormones, and vitamins. Albumin accounts for about 60% of the total mass in plasma, the next five most abundant proteins account for 25%, and the next 14 proteins account for 12%.
Plasma is an important material for the analysis of autoantibodies. Plasma proteins, such as autoantibody profiles are one of the foundations of immunomics. Analysis of plasma proteins in patient plasma can help identify single biomarker candidates for disease mechanism studies, diagnosis, or confirmation of disease, predicting risk, monitoring prognosis, and assessing efficacy.
Fig.1 Immunomics is the application of high-dimensional techniques and proteomics is a part of immunomics. (Tay, S. H., et al., 2019)
Existing biomarkers are far from comprehensive and often lack specificity, and the rate of development of new biomarkers is very slow. Since proteins in the circulatory system reflect a person's physiology, current advances in plasma proteomics open exciting new avenues for research and clinical use. CD Genomics provides professional and reliable plasma proteomics analysis services for clients worldwide.
As high-abundance proteins in plasma often interfere with the detection of low-abundance proteins, the first step in plasma proteomics analysis services is to remove high-abundance proteins. To achieve more sensitive experimental results, we use an optimized combination of several different separation and purification techniques for the removal of high-abundance proteins, such as antibody-based affinity and dye-based affinity columns for the selective separation of high-abundance proteins.
Based on years of immunomics research, CD Genomics has accumulated extensive experience in the analysis and study of serum and plasma proteomes. Through in-depth collaboration, we facilitate immunomics-related projects for our clients. Please contact us for more information.
