In many cellular systems, differences in genomic sequence and structure between cells can have negative phenotypic consequences, for example, driving oncogenic or resistance behavior. However, the immune system exploits DNA sequence variability in response to a wide range of antigens. CD Genomics offers specialized single-cell genomics services to explore the cancer ecosystem and changes in the TCR and BCR profiles in the immune system.
Single-cell genomics aims to provide new perspectives on our understanding of genetics by bringing the study of the genome to the cellular level. These tools are opening new areas of research by dissecting the impact and contribution of individual cells to the immune system. For example, it is now possible to use single-cell genomics to assess the role of gene mosaics in normal physiology and disease and to determine the contribution of genetic heterogeneity within tumors in cancer development or treatment response.
A key part of obtaining genetic information from single cells is to amplify a single copy of the genome while minimizing the introduction of artificial factors such as amplification bias, genome loss, mutations, and chimeras. Currently, there are three main genome-wide amplification (WGA) protocols. Once WGA has been performed, the products can be examined by conventional quantitative methods, such as qPCR or DNA sequencing.
The task of the mammalian immune system is to protect the host from a wide range of threats. Single-cell analysis is an important tool used to understand how the immune population uses cellular diversity to achieve this breadth and flexibility, especially during dynamic processes such as differentiation and antigen response. CD Genomics provides professional single-cell genomics services to promote your immunomics project.
CD Genomics brings together experts in sample handling, sequencing experiments, and data processing. With the ability to sequence whole genomes of multiple sample types, we help our customers sequence and analyze the diverse whole genomes of immune cells as a means of analyzing complex immune processes. Please contact us for more information.
