Advances in single-cell RNA sequencing (scRNA-seq) have made the comprehensive analysis of the immune system possible, which promotes our understanding of the immune system. CD Genomics provides professional and reliable single-cell transcriptomics services for immune cells to promote your immunomics project.
Prior to the development of scRNA-seq techniques, the discovery of new cell subpopulations required the use of cell surface markers. Although these methods are powerful, they required prior guesswork or knowledge to discover various immune cell types. The development of high-dimensional single-cell technologies has enabled an unbiased and alternative workflow that allows cells to be sequenced without prior knowledge of the genes and proteins of interest and grouped according to their transcriptional characteristics.
scRNA-seq provides a powerful approach to unraveling the heterogeneity of the immune system to study innate immune processes as well as disease pathogenesis and progression at high resolution. scRNA-seq has the unbiased potential to be used to discover healthy and diseased cellular states in different systems, enabling the discovery of disease-causing immune cell populations and revealing key regulators of immune response and pathogenicity.
Stochastic patterns of gene expression between cells in "homogeneous" populations may be central to how the immune system generates such a wide range of responses to maintain homeostasis and fight infection. The development of single-cell genomic approaches offers the exciting possibility of conducting these types of studies in a genome-wide manner to uncover unexpected and potentially stochastic variability in immune cell populations.
Developmental processes are driven by a series of transcriptional changes that allow cells to differentiate and commit to a specific lineage and eventual cell type. The ability to detect discrete cell subtypes using single-cell analysis to capture cells spanning multiple developmental stages in an unbiased manner and then reconstruct their developmental progression provides a unique approach to studying cellular decision-making and differentiation.
ScRNA-seq broadens our understanding of the true intermediate links in blood differentiation, the lineage relationships between different subpopulations, and the developmental checkpoints and blockages that accompany diseases, and is used to unlock broader biological questions about the nature of cell differentiation. CD Genomics offers single-cell transcriptomics services for immune cells to help our clients to decipher the heterogeneity of immune cells and the immunization process.
CD Genomics has an advanced sequencing platform to help clients discover unidentified cell types, cell states, and biologically significant cell heterogeneity, as well as to reconstruct genealogical progression in various developmental processes of the immune system. Please contact us for more information.
